A/Professor Rob Pike

MIIN Member

Department of Biochemistry and Molecular Biology
Monash University
+61399053923
rob.pike@med.monash.edu.au

Research Activities:

Investigations into the specificity and role of complement proteases
The response of host cells to bacterial proteases
Specificity and role of bacterial proteases
Specificity and role and of active and inactive proteases of the scabies mite

Techniques/Expertise:

Protein chemistry
Enzymology
Phage display mapping of enzyme specificity and binding specificity
Protein purification

Collaborations:

NHMRC Program grant: Phil Bird, James Whisstock, Steve Bottomley (all Monash University Department of Biochemistry)
Eleanor Mackie (Veterinary School, University of Melbourne)
CRC for Oral Health Sciences: Paul Hertzog (Monash Institute of Medical Research), Neil O’Brien-Simpson (Dental School, University of Melbourne)
Bacterial proteases: Prof Jan Potempa (Jagiellonian University, Poland), Liz Hartland (Monash University Department of Microbiology)
Scabies proteases: Prof Dave Kemp (Queensland Institute of Medical Research)

Animal Disease Models:

None in-house
Using model of periodontal disease with Neil O’Brien-Simpson
Using models of osteoclast differentiation and bone repair with Eleanor Mackie

Genetically Modified Animals:

PAR-1 and PAR-2 null mice

Existing Websites:

http://www.med.monash.edu.au/biochem/staff/pike.html

Lab Group Personnel:

1 post-doctoral fellow
3 research assistants
5 PhD students